Plunc

Palate, lung and nasal epithelium associated

Identifiers

PLUNC; LPLUNC3; LUNX; NASG; SPLUNC1; SPURT; bA49G10.5

External IDs

OMIM: 607412 MGI: 1338036 HomoloGene: 7895 GeneCards: PLUNC Gene

Gene Ontology
Molecular function	• molecular_function • lipid binding
Cellular component	• extracellular region
Biological process	• innate immune response
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 20:
31.82 – 31.83 Mb

Chr 2:
153.97 – 153.97 Mb

PubMed search

[1]

[2]

Palate, lung, and nasal epithelium carcinoma associated protein (PLUNC) is a gene encoding a secretory protein. It is also called Secretory protein in upper respiratory tracts (SPURT). In humans, it is encoded by the PLUNC gene.^[1]^[2]

1 Function
2 References
3 Further reading
4 External links

Function

This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The exact biological function of this gene is not known, however, it has been suggested to be involved in inflammatory responses to irritants in the upper airways. It may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only two is known.^[3]

References

^ Bingle CD, Bingle L (October 2000). "Characterisation of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern". Biochim. Biophys. Acta 1493 (3): 363–7. doi:10.1016/S0167-4781(00)00196-2. PMID 11018263.
^ Iwao K, Watanabe T, Fujiwara Y, Takami K, Kodama K, Higashiyama M, Yokouchi H, Ozaki K, Monden M, Tanigami A (February 2001). "Isolation of a novel human lung-specific gene, LUNX, a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer". Int. J. Cancer 91 (4): 433–7. doi:10.1002/1097-0215(200002)9999:9999<::AID-IJC1059>3.0.CO;2-B. PMID 11251963.
^ "Entrez Gene: PLUNC". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51297.

Zhang B, Nie X, Xiao B, et al. (2003). "Identification of tissue-specific genes in nasopharyngeal epithelial tissue and differentially expressed genes in nasopharyngeal carcinoma by suppression subtractive hybridization and cDNA microarray.". Genes Chromosomes Cancer 38 (1): 80–90. doi:10.1002/gcc.10247. PMID 12874788.
Garcia-Caballero A, Rasmussen JE, Gaillard E, et al. (2009). "SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage.". Proc. Natl. Acad. Sci. U.S.A. 106 (27): 11412–7. doi:10.1073/pnas.0903609106. PMC 2708735. PMID 19541605. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2708735.
Zhang BC, Zhu SG, Xiang JJ, et al. (2003). "[Analysis of splicing variants in NASG 3'UTR, down-regulated in nasopharyngeal carcinoma, and its expression in multiple cancer tissues]". Ai Zheng 22 (5): 477–80. PMID 12753706.
Dagle JM, Lepp NT, Cooper ME, et al. (2009). "Determination of genetic predisposition to patent ductus arteriosus in preterm infants.". Pediatrics 123 (4): 1116–23. doi:10.1542/peds.2008-0313. PMC 2734952. PMID 19336370. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2734952.
{{cite journal |author=Bryborn M, Halldén C, Säll T, Cardell LO |title=CLC- a novel susceptibility gene for allergic rhinitis? |journal=Allergy |volume=65 |issue= 2 |pages= 220–8 |year= 2010 |pmid= 19650845 |doi= 10.1111/j.1398-9995.2009.02141.x }
Cheng M, Chen Y, Yu X, et al. (2008). "Diagnostic utility of LunX mRNA in peripheral blood and pleural fluid in patients with primary non-small cell lung cancer.". BMC Cancer 8: 156. doi:10.1186/1471-2407-8-156. PMC 2424066. PMID 18513434. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2424066.
Zhou HD, Li GY, Yang YX, et al. (2006). "Intracellular co-localization of SPLUNC1 protein with nanobacteria in nasopharyngeal carcinoma epithelia HNE1 cells depended on the bactericidal permeability increasing protein domain.". Mol. Immunol. 43 (11): 1864–71. doi:10.1016/j.molimm.2005.10.021. PMID 16364440.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Zhou HD, Fan SQ, Zhao J, et al. (2006). "Tissue distribution of the secretory protein, SPLUNC1, in the human fetus.". Histochem. Cell Biol. 125 (3): 315–24. doi:10.1007/s00418-005-0070-4. PMID 16195890.
Sentani K, Oue N, Sakamoto N, et al. (2008). "Gene expression profiling with microarray and SAGE identifies PLUNC as a marker for hepatoid adenocarcinoma of the stomach.". Mod. Pathol. 21 (4): 464–75. doi:10.1038/modpathol.3801050. PMID 18204429.
Bingle CD, Gorr SU (2004). "Host defense in oral and airway epithelia: chromosome 20 contributes a new protein family.". Int. J. Biochem. Cell Biol. 36 (11): 2144–52. doi:10.1016/j.biocel.2004.05.002. PMID 15313462.
Campos MA, Abreu AR, Nlend MC, et al. (2004). "Purification and characterization of PLUNC from human tracheobronchial secretions.". Am. J. Respir. Cell Mol. Biol. 30 (2): 184–92. doi:10.1165/rcmb.2003-0142OC. PMID 12920053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
He Y, Ding YQ, Huang ZX, Yao KT (2007). "[Association of the coding region single nucleotide polymorphisms in PLUNC gene with nasopharyngeal carcinoma]". Zhonghua Yi Xue Za Zhi 87 (22): 1553–5. PMID 17785110.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
Wang WB, Cui YG, Yao SY (2008). "[Message RNA expression of LUNX, CK19 and CEA genes in NSCLC with micrometastasis in lymph nodes]". Zhonghua Zhong Liu Za Zhi 30 (2): 121–4. PMID 18646695.
Bartlett JA, Hicks BJ, Schlomann JM, et al. (2008). "PLUNC is a secreted product of neutrophil granules.". J. Leukoc. Biol. 83 (5): 1201–6. doi:10.1189/jlb.0507302. PMID 18245229.
Zhou HD, Li XL, Li GY, et al. (2008). "Effect of SPLUNC1 protein on the Pseudomonas aeruginosa and Epstein-Barr virus.". Mol. Cell. Biochem. 309 (1-2): 191–7. doi:10.1007/s11010-007-9659-3. PMID 18049866.
Ghafouri B, Kihlström E, Tagesson C, Lindahl M (June 2004). "PLUNC in human nasal lavage fluid: multiple isoforms that bind to lipopolysaccharide". Biochim. Biophys. Acta 1699 (1-2): 57–63. doi:10.1016/j.bbapap.2004.01.001. PMID 15158712.
Bingle L, Barnes FA, Cross SS, et al. (2007). "Differential epithelial expression of the putative innate immune molecule SPLUNC1 in cystic fibrosis.". Respir. Res. 8: 79. doi:10.1186/1465-9921-8-79. PMC 2203987. PMID 17988392. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2203987.

External links

MeSH PLUNC+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Plunc

Contents

Function

References

Further reading

External links